|
T12268 |
NTP42
|
|
Prostaglandin Receptor
,
PPAR
|
|
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM) |
|
T11339 |
Furegrelate sodium
|
U-63557A |
PPAR
|
|
|
|
T8900 |
Seralutinib
|
GB002 |
PDGFR
|
|
Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension. |
|
T2561 |
Macitentan
|
ACT-064992 |
Apoptosis
,
Endothelin Receptor
|
|
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). |
|
T14782 |
Brilaroxazine
|
RP5063 |
Dopamine Receptor
,
5-HT Receptor
|
|
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... |
|
T3148 |
MK-571 sodium
|
L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid |
Leukotriene Receptor
,
LTR
|
|
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... |
|
T60388 |
MIF098
|
|
Others
|
|
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be ... |
|
T3216 |
Selexipag
|
NS-304,ACT-293987,Uptravi |
Others
,
Prostaglandin Receptor
|
|
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH). |
|
T11339L |
Furegrelate
|
|
PPAR
|
|
FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. |
|
T0467 |
Sildenafil citrate
|
UK-92480 citrate |
Apoptosis
,
PDE
,
Autophagy
|
|
Sildenafil citrate (UK-92480 citrate) , a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) Inhibitor, is used extensively for erectile dysfunction and less commonly for pulmonary hypertensio... |
|
TP1016L |
Aviptadil Acetate
|
Vasoactive Intestinal Peptide acetate salt |
RAAS
,
SARS-CoV
|
|
Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for research on pulmona... |
|
T6968 |
Riociguat
|
BAY 632521 |
Guanylate cyclase
|
|
Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension. |
|
T1655 |
Ambrisentan
|
BSF-208075,BSF 208075,LU 208075 |
Endothelin Receptor
|
|
Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but ha... |
|
T6264 |
Bosentan
|
Actelion,Ro 47-0203,Benzenesulfonamide |
Endothelin Receptor
|
|
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th... |
|
T27624 |
Iptakalim Hydrochloride
|
|
Potassium Channel
,
AChR
|
|
Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2... |
|
T13193 |
TPN171
|
|
PDE
|
|
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer l... |
|
T36008 |
Nebentan potassium
|
|
|
|
Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan potassium inhibits [125I] endothelin-1 binding to cloned ... |
|
T19660 |
QCC-374
|
QCC374 |
|
|
QCC-374 is a prostanoid agonist. It potentially for the treatment of pulmonary arterial hypertension. |
|
T15238 |
Epoprostenol sodium
|
Prostaglandin I2 sodium salt,Prostacyclin sodium salt,Flolan |
Others
|
|
Epoprostenol sodium is a potent inhibitor of platelet aggregation used in pulmonary hypertension and transplantation. |
|
T24389 |
LASSBio-1366
|
LASSBio 1366 |
|
|
LASSBio-1366 is an agonist of adenosine A2a receptor that acts by attenuating the progression of monocrotaline-induced pulmonary hypertension. |
|
T30501 |
BMS-193884
|
BMS193884,BMS 193884 |
|
|
BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension. |
|
T20024 |
Tadalafil, (6R ,12aS)-
|
Tadalafil (6R ,12aS)- Lilly,Tadalafil specified impurity A,(-)-Tadalafil (6R ,12aS) diastereomer |
|
|
Tadalafil is a carboline derivative and Phosphodiesterase 5 Inhibitor. It is used primarily to treat Erectile dysfunction, Benign Prostatic Hyperplasia, and Primary Pulmonary Hypertension. |
|
T25568 |
Ketanserinol
|
Reduced ketanserin |
|
|
Ketanserinol is the metabolite of ketanserin. Ketanserin is a hypotensive drug with 5-HT2 receptor antagonism, used to reverse pulmonary hypertension caused by protamine. |
|
T11935 |
Macitentan (n-butyl analogue)
|
|
Others
|
|
Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibros... |
|
T36210 |
15-keto Treprostinil (sodium salt)
|
|
|
|
15-keto Treprostinil is an impurity found in treprostinil , which is a stable analog of prostaglandin I2 with a longer plasma half-life. Formulations containing treprostinil are used for the treatment of primary pulmonar... |
|
T6959 |
PRX-08066 Maleic acid
|
|
5-HT Receptor
|
|
PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2. |
|
T80075 |
Cyclo(Ala-Arg-Gly-Asp-Mamb)
|
XJ735 |
Integrin
|
|
Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective antagonist of the RGD peptide with potential applications in pulmonary arterial hypertension research [1]. |
|
T70704 |
RB-005
|
|
|
|
RB-005 is a potent sphingosine kinase isoform 1 (SK1) inhibitor, which may serve as therapeutic agent for proliferative diseases, including hypertension. RB-005, (IC(50) = 3.6 μM), which also induced proteasomal degradat... |
|
T74406 |
BRD2889
|
|
|
|
BRD2889, an analog of the alkaloid piperlongumine, serves as a potent modulator of the GSTP1-ISCU axis in pulmonary hypertension (PH) [1]. |
|
T16779 |
Rodatristat ethyl
|
RVT-014,KAR5585,RVT-1201 |
5-HT Receptor
,
Hydroxylase
|
|
Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hyperten... |
|
TP2000 |
MM 07
|
|
|
|
Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in... |
|
T60429 |
SY-LB-57
|
|
|
|
SY-LB-57 is a highly effective agonist of bone morphogenetic protein (BMP) receptor signaling. SY-LB-57 can be used in studies of conditions such as bone fracture and pulmonary arterial hypertension [1]. |
|
T79223 |
BMPR2-IN-1
|
|
|
|
BMPR2-IN-1 (Compound 8a), is a potent inhibitor of BMPR2, exhibiting an IC50 value of 506 nM and a Kd of 83.5 nM. It is utilized in the study of various diseases including pulmonary arterial hypertension, Alzheimer's dis... |
|
T78721 |
Smurf1-IN-1
|
|
E1/E2/E3 Enzyme
|
|
Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in a rat model of pulmonary hypertension [1]. |
|
T79573 |
ET receptor antagonist 1
|
|
Estrogen Receptor/ERR
|
|
ET Receptor Antagonist 1 (compound 16h), with an IC50 value of 0.18 nM, is an orally active agent that can be utilized for pulmonary arterial hypertension (PAH) research. It has demonstrated efficacy in mitigating monocr... |
|
T79574 |
ET receptor antagonist 2
|
|
Estrogen Receptor/ERR
|
|
ET Receptor Antagonist 2 (Compound 16j) is an orally active ET receptor antagonist with an IC50 of 0.22 nM, suitable for pulmonary arterial hypertension (PAH) research. It has been shown to mitigate monocrotaline-induced... |
|
T79575 |
ET receptor antagonist 3
|
|
Estrogen Receptor/ERR
|
|
"ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH) research. This compound demonstrates efficacy in mitigating ... |
|
T78076 |
PBR28
|
|
Others
|
|
PBR28, a TSPO modulator, holds potential for preventative research in Pulmonary Arterial Hypertension (PAH) and is instrumental in brain positron emission tomography (PET) imaging studies through its capacity for radioac... |
|
T73877 |
BQ-123 TFA
|
|
|
|
BQ-123 TFA, a potent and selective endothelin A (ETA) receptor antagonist, demonstrates an IC50 of 7.3 nM and a Ki of 25 nM. It effectively inhibits endothelin-1-induced proliferation of human pulmonary artery smooth mus... |
|
T62909 |
SGC agonist 2
|
|
|
|
SGC agonist 2 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 2 has potential for cardiovascular disease (heart failure, angina, pulmonary hypertension, myocardial infarction) and fibrotic disease (renal... |
|
T36405 |
Pro-Adrenomedullin (153-185), human
|
Pro-Adrenomedullin (153-185), human,H2N-Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu-OH |
|
|
Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaec... |
|
TP2214 |
Adrenomedullin (1-12), human
|
|
Others
|
|
Adrenomedullin (AM) (1-12), human, is a peptide with the sequence Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg. Adrenomedullin (AM) (1-12), human, was initially identified as a vasodilator, and as such, it has the abi... |
|
T65598 |
Cefminox sodium
|
|
|
|
Cefminox (Sodium) is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobi... |
|
T36007 |
Nebentan
|
|
|
|
Nebentan (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA... |
